46,xx testicular disorder of sex development – genetics home reference


46,XX testicular disorder of sex development is a condition in which individuals with two X chromosomes in each cell, the pattern normally found in females, have a male appearance. Financial markets futures People with this disorder have male external genitalia . 1 usd myr They generally have small testes and may also have abnormalities such as undescended testes (cryptorchidism) or the urethra opening on the underside of the penis (hypospadias). Canadian dollar to indian rupee exchange rate A small number of affected people have external genitalia that do not look clearly male or clearly female (ambiguous genitalia). Usd jpy exchange rate Affected children are typically raised as males and have a male gender identity.

At puberty, most affected individuals require treatment with the male sex hormone testosterone to induce development of male secondary sex characteristics such as facial hair and deepening of the voice (masculinization). Bloomberg stock futures market Hormone treatment can also help prevent breast enlargement (gynecomastia). Gbp usd rate Adults with this disorder are usually shorter than average for males and are unable to have children (infertile).

People normally have 46 chromosomes in each cell. Twd usd Two of the 46 chromosomes, known as X and Y, are called sex chromosomes because they help determine whether a person will develop male or female sex characteristics. Us market futures Females typically have two X chromosomes (46,XX), and males usually have one X chromosome and one Y chromosome (46,XY).

The SRY gene, normally located on the Y chromosome, provides instructions for making the sex-determining region Y protein. Financial market futures The sex-determining region Y protein causes a fetus to develop as a male.

In about 80 percent of individuals with 46,XX testicular disorder of sex development, the condition results from an abnormal exchange of genetic material between chromosomes ( translocation ). Pound exchange rate forecast This exchange occurs as a random event during the formation of sperm cells in the affected person’s father. The boxer rebellion tour The translocation causes the SRY gene to be misplaced, almost always onto an X chromosome. Gold forecast today If a fetus is conceived from a sperm cell with an X chromosome bearing the SRY gene, it will develop as a male despite not having a Y chromosome. Oil futures market This form of the condition is called SRY-positive 46,XX testicular disorder of sex development.

About 20 percent of people with 46,XX testicular disorder of sex development do not have the SRY gene. Future marketing trends 2015 This form of the condition is called SRY-negative 46,XX testicular disorder of sex development. Aud in usd The cause of the disorder in these individuals is often unknown, although changes affecting other genes have been identified. Usd to euro chart Individuals with SRY-negative 46,XX testicular disorder of sex development are more likely to have ambiguous genitalia than are people with the SRY-positive form.

SRY-positive 46,XX testicular disorder of sex development is almost never inherited. Stock market future predictions 2015 This condition results from the translocation of a Y chromosome segment containing the SRY gene during the formation of sperm (spermatogenesis). Rmb to usd Affected people typically have no history of the disorder in their family and cannot pass on the disorder because they are infertile.

In rare cases, the SRY gene may be misplaced onto a chromosome other than the X chromosome. Euro usd chart This translocation may be carried by an unaffected father and passed on to a child with two X chromosomes, resulting in 46,XX testicular disorder of sex development. Exchange rate aud to usd In another very rare situation, a man may carry the SRY gene on both the X and Y chromosome; a child who inherits his X chromosome will develop male sex characteristics despite having no Y chromosome.

The inheritance pattern of SRY-negative 46,XX testicular disorder of sex development is unknown. Currency converter zar to usd A few families with unaffected parents have had more than one child with the condition, suggesting the possibility of autosomal recessive inheritance. Usd to ruble exchange rate Autosomal recessive means both copies of a gene in each cell have mutations. Dollar to pound chart The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.